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 Permanent members

Prof. Antonio de la Hoz Ayuso

Prof. Ángel Díaz Ortiz

Dra. Ana Sánchez-Migallón Bermejo

Dr. José Ramón Carrillo Muñoz

Dra. María Pilar Prieto Nuñez-Polo

Dra. Mª Victoria Gómez Almagro

Dr. Aldrik H. Velders



Prof. Antonio de la Hoz

Antonio de la Hoz is Professor in Organic Chemistry in the University of Castilla-La Mancha. He obtained his Ph. D. from the Universidad Complutense in Madrid in 1986 under the supervision of Prof. José Elguero and Carmen Pardo. After postdoctoral research in 1987 with Prof. Mikael Begtrup at the Danmarks Tekniske Høskole he joined the Faculty of Chemistry of the Universidad de Castilla-La Mancha in Ciudad Real in 1988 as an Assistant Professor. In 1993 he worked under the supervision Prof. André Loupy in the Université de Paris-Sud in Microwave Assisted Organic Chemistry. Prof. de la Hoz has authored over 200 scientific publications 120 of them related to Microwaves in Organic Synthesis. Dr. de la Hoz has been a foundation member of the Spanish Green Chemistry Network. His current research interests focus on Green methodologies, microwave activation, mechanochemistry, flow methodologies and solvent-free reactions, and the applications of heterocyclic compounds in material and supramolecular chemistry.

Research activities and interests

Development of devices and processes with Green methodologies and conditions: Microwave irradiation, Flow reactions, mechanochemistry

Angel Diaz Ortiz
Ángel Díaz-Ortiz was born in Tomelloso (Spain) and obtained his PhD from the Institute of Medicinal Chemistry (Madrid) in 1988. After postdoctoral research at Laboratorios Alter S. A. he joined the Faculty of Chemistry of the Universidad de Castilla-La Mancha (UCLM). Presently, he is Full Professor of Organic Chemistry. His research interests encompass new synthetic methods including the preparation of heterocyclic compounds by cycloaddition reactions in a microwave environment.
Ana Sanchez Migallon Bermejo
Jose Ramon Carrillo

José Ramón Carrillo Muñoz was born on June 15th 1960 in Ciudad Real (Spain). In June 1982 she obtained his degree in Chemistry at the Universidad Complutense of Madrid, He obtained his Ph. D. from the Universidad of Castilla-La Mancha in 1993 under the supervision of Prof. Enrique Díez-Barra. He completed a predoctoral stay in 1992 and a postdoctoral stay during the 1993-94 academic year at the Université the Paris-Sud, both under the supervision of Professor André Loupy.

Since 1983 he is Assistant Professor in the School of Agricultural Engineers of  Castilla-La Mancha.

His current investigation is mainly focused in Development of new materials under microwave together with the employed environmentally friendly chemical process and Computational Chemistry.




Maria Pilar Prieto

Pilar Prieto Núñez-Polo was born on March 6th 1966 in Ciudad Real (Spain). In Juny 1989 she obtained her degree in Chemistry at the Universidad Complutense of Madrid. During this time she spend 6 months in the BASF Industry (Mannheim). In 1990 she worked in the Medicinal Institut of CSIC in Madrid. Then,  she moved at the University of Castilla-La Mancha (UCLM) in 1991, where she obtained her Ph. D. from the UCLM under the supervision of Prof. Ángel Díaz Ortiz in 1995. The main focus of her thesis was  the application of Microwave Irradiation as alternative and environmentally friendly energy sourced in the development of chemical process. During the development of her Ph. D. thesis, she also performed in 1994 a pre-doctoral stay in the Université the Paris–Sud under the supervision of Prof. André Loupy. At this time she worked with a prototype monomode microwave reactor.

Afterwards, she realized two post-doctoral stays. One of them in the Technische Hochshule of Darmstadt under the supervision of Prof. Hans Neunhoeffer and the other one was in the University of Basque Country under the supervision of Prof. Fernando Cossío. It was the latter wich gave her a wider vision of the Computational Chemistry. To gain a deeper insight into that field, she performed two additional short stays in the Medical Chemistry Institute of CSIC in Madrid under the supervision of Ibon Alkorta, and another one with Prof. Fernando Cossío.

She is currently a professor at the Faculty of Chemical Sciences and Technologies of Castilla-La Mancha. Prof. Prieto has authored 70 scientific publication and 8 book chapters. She has supervised 3 DEAs, 7 masters, and 5 PhD projects (Abel de Cozar Ruano, Cristina Cebrián Ávila, Antonio Manuel Rodriguez, Iván Torres Moya and Raúl Martín Lozano). She is currently supervising 2 PhD projects (Beatriz Donoso Jurado and Jesús Herrera Herreros).

Her current investigation is mainly focused in two fields:

-          Development of new materials under microwave together with the employed environmentally friendly chemical process, with applicability as Organic Field Effect Transistors (OFETs) and mainly as Organic Optical waveguide

Diapositiva presentación (Mi tesis en 3 min)

Organic multifunctional semiconducting derivatives have attracted a great deal of attention in the last decade due to their potential applications in organic electronics, such as organic field-effect transistors (OFETs), sensors, photodetectors and optical waveguide devices. However, in the vast majority of these applications, a high degree of organization at the mesoscale is required. To achieve organized materials, the operation of non-covalent forces between organic molecules is known to afford self-assembled, functional microstructures. Photonics are at the forefront of the potential applications of these materials. Thus, the ability to control the light propagation properties of self-assembled structures has led to significant advances in organic waveguides, color conversion and light amplification. These micro-/nanoscale optical elements can serve as fundamental components in miniaturized photonic integrations with applications in optical communication, information processing, optical sensing or optical logic circuits. One of the main challenges in the future for miniaturized optoelectronic devices is the use of nano- to micron-sized waveguides that propagate light efficiently. Hence, the fabrication of nanowaveguides by the self-assembly of organic molecules is a subject of significant interest. On the other hand, crystalline organic materials inherently have a perfect molecular arrangement, e.g., the elimination of crystal boundaries, and this leads to a high carrier mobility and good thermal stability.



-          Computational Chemistry. In this area she is interested in the study of some reaction mechanisms which are claimed to be improved under microwave irradiation. Theoretical calculations can be used as a tool to model those mechanisms and evaluate the real influence of the microwave irradiation on them.

It is also a powerful tool for calculating molecular properties, such as geometry, polarity, topology and energy of frontier molecular orbital, energy of rearrangement, absorption and emission spectra, RAMAN spectra, aggregation, etc.

Ph. D. Students: Beatriz Donoso and Jesús Herrera Herreros.

Post-doctoral Student: Iván Torres Moya.

Contact info:

MaríaPilar.Prieto@uclm.es  / Edificio Marie Curie – Avda. Camilo José Cela s/n – 13071 Ciudad Real /

Tfno. 926295300 Ext. 3487

Victoria Gomez Almagro

Maria Victoria Gómez Almagro was born the 14th January 1978 in Ciudad Real (Spain). In July 2001, she obtained her degree in Chemistry with an honour additional at the University of Castilla-La Mancha (UCLM). Having finished her degree, she joined to the group of Prof. George Fleet from Oxford University (UK) under the supervision of Dr. Tim Claridge for a few months, giving her an intimate knowledge of the NMR spectroscopy on Synthetic Peptides. In January 2002, she started as a Ph.D candidate (Ministerio de Educación y Ciencia fellowship) at the Faculty of Chemistry (UCLM) under the supervision of Dr. Andres Moreno and Prof. Antonio de la Hoz. She has investigated the application of Microwave Irradiation as alternative and environmentally friendly energy source in the development of chemical processes. A stay of a few months at the Instituto de Tecnologia Química de Valencia (Spain), under the supervision of Prof. Avelino Corma, gave her a wider vision of the effects of the zeolite structure on the chemical processes mentioned above. In February 2006, she got her PhD degree, getting the grade of Chemistry European Doctor (cum Laude). She spent more than two years (August 2006-November 2008) at the Supramolecular Chemistry and Technology group of Prof. David Reinhoudt (University of Twente, The Netherlands) as postdoc researcher- Marie Curie Intraeuropean Fellowship (EIF) -, at the NMR & MS department under the supervision of Dr. Aldrik Velders. The Project involved the research, design and development of NMR probes with microfluidic and nanofluidic components. In February 2009, she continued her research at the Instituto Regional de Investigación Cientifica Aplicada (IRICA) (UCLM) , and focused mainly on the development of a project awarded by the European Commission -Marie Curie Reintegration program (ERG) – with title “On-line monitoring of microwave-assisted chemical reactions by rf-microcoils“. In March 2011, she started as Senior Researcher INCRECYT, within a research program from the Albacete Science and Technology Park, at the IRICA where she supervised 2 PhD projects within the group (Antonio Rodriguez and Alberto Juan) and within the topic of small-volume NMR spectroscopy with the use of radiofrequency microcoils. Since April 2015, she continues her research projects as Ramon y Cajal researcher within the same group, supervising the PhD thesis of Rosa Maria Sanchez and Jose Miguel Mateo.

Research activities.

Radiofrequency microcoils represent an efficient and cheap alternative to enhance the sensitivity of NMR for mass-limited samples. For a constant length-to-diameter ratio, the sensitivity of an NMR coil is inversely proportional to its diameter. It also means that when the detection coil is miniaturized, the sample volume can be brought down to the nanoliter regime. In our research, we are focused on the use of planar spiral microcoils integrated on top of a glass substrate (NMR-chip (figure)) for the optimization of continuous-flow chemical processes when the detection volume is in the nanoliter regime. This research topic is developed in collaboration to Prof. Dr. Aldrik Velders from University of Wageningen.


Thus, Antonio M. Rodriguez  was focused on the development of methodologies for kinetic studies and monitorization of processes by combining NMR microcoils with continuous flow microreactors, while Alberto Juan developed his research on the development of methodologies and setups for the analysis of continuous flow photo-assisted reactions by NMR-microcoils. Traditional methods to optimize reaction conditions are not adequate because they require stopping the reaction and usually the time required for analysis is longer than the reaction time itself. Therefore, the use of an NMR-chip hyphenated to any type of reactor when the whole system works on continuous flow enables the monitoring of the reaction progress and the optimization of the reaction conditions in short time, with very small reaction volume and consuming very low energy.

In December 2014, Rosa M. Sanchez Donoso and Jose Miguel Mateo Gonzalez started their PhD projects within the field of NMR-microcoils. They work in the design of new NMR microcoils together with the development of new methologies for the study of certain protein surfaces. This is the main goal of the National Project awarded t0 Dr. Gómez and her research team (2015-2018).

NMR spectroscopy as a tool for the investigation of different phenomena.

NMR spectroscopy is our tool of research to study different phenomena within the group and in collaboration with other research groups (from University of Texas, University of Zaragoza, University of Castilla-La Mancha, University of Twente). The research is related to four main different fields: (Photo)- Flow Chemistry, Food science, Reaction monitoring, Materials Science, Supramolecular Chemistry and metabolomics:

NMR can be used as the main technique to provide structural information about unknown compounds in a mixture or about the structural characterization of an isolated compound, i.e. a natural product isolated from a foodstuff. NMR is applied in this sense for the structural determination of compounds like flavonol 3-O-Glycosides of red grape; Peonidin 3,7-O-β-Diglucoside and other unusual anthocyanins isolated from Garnacha Tintorera (Vitis vinifera L.) Grapes; 10-Acetyl-pyranoanthocyanins, interesting natural products found in red wines and/or grapes. In addition,  we also use NMR spectroscopy to study a certain behavior within a reaction media like for example the tendency of some compounds to form supramolecular structures maintained by non-covalent bonds, the study of the size of these architectures, the supramolecular stability in different reaction media, the location of nanoparticles encapsulated within a macromolecule, and the size of metal nanoparticles.  To reach that goal, we carry out NMR experiments like PFGSE experiments, in addition to the above mentioned experiments, which resulted very appropriate and provide detailed information on molecular structure at the atomic level. A different approach in the use of  NMR spectroscopy is in metabolomics. There, the metabolites extracted from cells are studied under a given set of conditions to gain insight into changes in cell metabolism after addition of a certain treatment. In this sense, we collaborate with the Faculty of Medicine (UCLM) in the search of a new strategy, by using the antioxidant CoQ, to sensitize glioblastoma cells to the effect of chemotherapeuticals in central nervous system tumors. In relation with this last project, we had in the group the PhD defense of Maria Moreno.

MariaVictoria.Gomez@uclm.es / Edificio Marie Curie – Avda. Camilo José Cela s/n – 13071 Ciudad Real /

Aldrik Velders

Aldrik Velders (1970) studied Chemistry at the University of Utrecht (NL) with Prof. Blasse and Prof. Andries Meijerink, and at the Universityof Pavia(I) with Prof. Luigi Fabbrizzi. In 1995 he started as graduate student at the University of Leiden (NL) on antitumor chemistry with Prof. Jan Reedijk, was visiting scientist in the group of Prof. Enzo Alessio in Trieste(I), and obtained his PhD degree in 2000 with the thesis Ruthenium Complexes with Heterocyclic Nitrogen Ligands. He spent his post-doc years at the Centre for Magnetic Resonance under guidance of Prof. Bertini and Prof. Luchinat (Florence, I) and as Marie Curie Fellow at Molteni Farmaceutici (Scandicci, I). In 2004 he started as assistant professor in the SupraMolecular Chemistry and Technology group of prof. David Reinhoudt at theUniversity of Twente, also heading the NMR & MS department. Since 2009 he is associate professor and currently in the BioMedical Chemistry group. His research interests go from (dynamic) supramolecular chemistry in solution and on (flat, fluidic and functional nanoparticle) surfaces, to (bio)nanotechnological applications of microfluidics, fluorescence and NMR spectroscopy. He recently moved to Wageningen University where he is the chair of BioNanoTechnology group and  has a major research line focused on further continuing to develop microfluidic NMR hardware and Nano-NMR spectroscopy. In July 2011, the management board of the University of Castilla-La Mancha approved the entitlement of “profesor colaborador honorifico”, allowing him to become member of the Microwave and Sustainable Organic Chemistry group. Since July 2013 he is the director of the Wageningen Nuclear Magnetic Resonance Centre (WNMRC).

 Research interests as a member of the MSOC group.

One of my major areas of interests regards “Nano NMR Spectroscopy”. NMR  spectroscopy is among the most powerful analytical tools developed in the last century, but it has, yet, only played a minor role in the emerging fields of micro- and nanotechnology. NMR spectroscopy is nevertheless a powerful tool also in these new research areas, which for example we have exploited for the analysis of nanoparticles and nanoliter sample volumes.

Non-functionalized nanoparticles are notoriously hard to characterize, but in collaboration with prof. Richard Crooks from the University of Texas at Austin (TX, USA) some useful strategies have been developed. In particular, we have used high-resolution solution-state NMR spectroscopy to characterize the structure of non-functionalized Pd dendrimer-encapsulated nanoparticles (DENs). Hereto, first, a full analysis was done of the homo- and heteronuclear 1D and 2D NMR data of the fourth-generation hydroxyl-terminated poly(amidoamine), PAMAM, dendrimer (G4‑OH), which is a 15 kDa macromolecule containing over a 1000 protons that show severely overlapping signals due to the high (pseudo-)symmetry. Analyzing G4‑OH(Pd55) DENs by 1H and diffusion-ordered NMR spectroscopy then unambiguously demonstrates that single nanoparticles are encapsulated within individual dendrimers.[1] Consecutively, simple 1D 1H‑NMR data of Pd nanoparticles encapsulated within sixth-generation hydroxyl-terminated PAMAM (a 60 kDa dendrimer) allows determination of the size of Pd DENs (G6-OH(Pdx)) ranging from 55, 147, 200 to 250 atoms. Solution-state 1H NMR spectroscopy thus provides a straightforward tool to characterize nanometer-size nanoparticles,[2] where otherwise advanced and less accessible techniques, e.g. TEM, have to be used, that moreover only provide sampled and ex-situ data.

Analysis of mass-limited samples with NMR spectroscopy remains a major challenge, which has triggered the development of expensive and technologically demanding solutions as cryogenically cooled coils in so-called cryoprobes and hyperpolarization strategies.  A relatively cheap alternative approach regards the use of miniaturized coils and, over the past two decades, microcoils of different geometries have in fact proven to be a successful sensitivity enhancement strategy.[3] We are particularly interested in microfluidic chip designs with planar spiral coils and detection volumes in the lower nanoliter range. These NMR chips have proven to be very efficient for on-flow reaction monitoring studies by 1H NMR spectroscopy, optimizing reaction conditions utilizing only minute amounts of starting material and solvents.[4] Alternatively, under static conditions also supramolecular interactions can be investigated as proven by a 19F NMR study on the interaction of hexafluorophosphate anions with cyclodextrin host molecules.[5] We are currently exploring the use of the microcoil-on-a-chip concept for low-gamma nuclides as well, and integrate the chips in more complicated hyphenated microfluidic set ups.

Selected References:

[1] M.V. Gomez, J. Guerra, A.H. Velders, R.M. Crooks, J. Am. Chem. Soc., 341–350 (2009). [2] M.V. Gomez, J. Guerra, V.S. Myers, R.M. Crooks, A.H. Velders, J. Am. Chem. Soc., 14634–14635 (2009). [3] R. M. Fratila, A. H. Velders, Annu. Rev. Anal. Chem. 2011, 227-249 [4] M.V. Gomez, H.J.J. Verputten, A. Díaz-Ortíz, A. Moreno, A. de la Hoz, A.H. Velders, Chem. Commun. 2010, 4514-4516 [5] M. V. Gómez, D. N. Reinhoudt, A. H. Velders, Small 2008, 4, 1293-1295.