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Recent publications and News
New publication on CIDNP hyperpolarization in a microfluidic chip in nature communications
cidnpIn this paper published in Nature Communications we show NMR chips with photo-CIDNP and broadband capabilities addressing two of the major limiting factors of NMR, by enhancing sensitivity as well as reducing cost and hardware complexity; the performance is compared to state-of-the-art instruments.
New research book on flow chemistry

New book edited by Janssen and our group on the applications of flow chemistry in drug discovery with chapters published by relevants researcher in the field. 

Editorial: Springer-Nature

Computational Chemistry and Microwaves
Diapositiva 1

 This review, published in Chem. Soc. Rev., provides an overview of the use of Computational Chemistry in MAOS to provide a theoretical understanding of the factors that can be used to explain the improvements in MAOS and how computational calculations can be used as a predictive tool.


Flexible optical waveguide

In collaboration with Prof. Chandrasekar we have described a new flexible optical waveguide

Microcrystals surface exhibit moderate flexibility and display mechanical compliance when cut precisely with sharp atomic force microscope cantilever tip, making them ideal candidates for building innovative T- and Δ-shaped optical junctions with multiple outputs.

Flow Cover
Flow Janssen

A paper on the Reformatsky and Blaise reaction in Flow in collaboration with JANSSEN, S.A. has been published in a special issue of Green Chemsitry on Flow chemistry and has been elected as the cover of the issue.


Hot Article Collection

An article of the group has been elected for the "HOT Article Collection" of the journal Nanoscale Advances.

The paper published in Nanoscale Adv., 2020,2, 3954-3962 describes the use of NMR spectroscopy to study the mechanism of formation of Pd and Au nanoparticles. 

Microcoils and NMR
micro RMN

NMR analysis of mass-limited samples remains a major challenge, which has triggered the development of expensive superconducting ultra-high field magnets, as well as of more expensive and technologically demanding solutions as cryoprobes and hyperpolarization schemes. Mass-limited samples could also benefit from the use of miniaturized coils, since the amplitude of the NMR signal is optimal when the sizes of the coil and sample match.

    In our group, we work on the design and fabrication of NMR-chips, rf-planar microcoil integrated on top of a glass substrate, and the construction of a small-volume NMR probe in which an optimized position for the NMR-chip allows the analysis of mass- and volume limited samples for different applications.

    In parallel, we are also focused on the integration of an NMR chip  with microreactors by developing continuous-flow hyphenated systems of different activation sources with nanoliter NMR spectroscopy. Alternative modes of activation, such as microwave irradiation and light-emitting diodes (LED) are employed. In this sense, a microwave-assisted continuous-flow microreactor was hyphenated with nanoliter-volume NMR spectroscopy, providing a rapid optimization of reaction conditions with low cost and reduced amount of solvents. The main advantage of the systems deals with the fact of allowing the division of the reaction volume -usually higher than the detection volume- into several zones -each of these ones exposed to the activation source for different times when working  under flow conditions-  and the analysis of each zone separately. Therefore, choosing the appropriate flow rate, experimental variables and NMR acquisition parameters, the necessary data points for optimizing the reaction conditions can be obtained in a single constant-flow experiment. This advantage is of highly importance specially when dealing with microwave as energy source where in most cases, the time required for analysis is longer than the reaction itself.

Microfluidics and Photo-CIDNP

We have shown that the sesibility of NMR can be enhaced untill unprecedent limits with a self-designed and buld technology.

This increase in sensibility is higher to tthe described with comercial systems and suposes an rebirth of the photo-CIDNP NMR methodology.

Thesse results have been done with NMR microcoils, designed in our group and low  Watts light sources. This results opens new possibilities in the research of biological systems and pocesses that requires low concentrations.

The results have been published in Nature Communications.http://rdcu.be/EnwU.

New textbook in flow chemistry
Book cover

We have participated in the second edition of the textbook FLOW CHEMISTRY.

The fully up-dated edition of the two-volume work covers both the theoretical foundation as well as the practical aspects. A strong insight in driving a chemical reaction is crucial for a deeper understanding of new potential technologies. New procedures for warranty of safety and green principles are discussed.

Filling the gap by covering fundamental reaction principles as well as current applications.

  • Provides examples of relevant commercial separation, automation, and analytical equipment.
  • New: Applications in photo-, electrochemistry and nanotechnology.
  • Editors:

    F. Darvas, Florida Int. U, USA; G. Dormán, ThalesNano, Hungary; V. Hessel, U Adelaide, Australia; S. Ley, U Cambridge, UK.


    our group has been accepted as associated partner in PhotoReact project.

    The PhotoReAct Innovative Training Network establishes a training network with 10 beneficiaries from academia and 4 beneficiaries from industry to tackle the challenges associated with photocatalysis in a coherent and comprehensive fashion.

    Prof. dr. Timothy (Tim) Noël. PhotoReAct Project Coordinator. University of Amsterdam

    Prof. Eli Zysman-Colman. University of St Andrews

    Prof. Paola Ceroni. University of Bologna 

    Prof. Kirsten Zeitler. Leipzig University 

    Prof. Dorota Gryko. Polish Academy of Sciences

    Prof. Cristina Nevado. University of Zürich

    Dr. Daniele Leonori. University of Manchester

    Dr. Géraldine Masson. ICSN-CNRS

    Dr. Maurizio Fagnoni and Dr. Stefano Protti. University of Pavia

    Prof. Ryan Gilmour. Universität Münster

    Dr. Kevin Huvaere. Copenhagen University

    Dr. Carin Seechurn and Dr. Peter Ellis.  JM’s Technology Centre. Oxfordshire, UK

    Dr. Gellert Sipos. MTA-ELTE "Lendület"

    Dr. Jesús Alcázar. Janssen-Cilag, S.A.