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Huntingtin in the amygdaloid basolateral complex is correlated with Vonsattel staging in Huntington’s disease 

Pablo Sanchez-Migallon Alicia Flores-Cuadrado Patricia Villanueva-Anguita 

Alberto Rabano Julia Vaamonde Daniel Saiz-Sanchez Alicia Mohedano-Moriano Veronica Astillero-Lopez Carmen Soriano-Herrador 

Alino Martinez-Marcos

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Brain Communications, Volume 8, Issue 1, 2026, fcaf502, https://doi.org/10.1093/braincomms/fcaf502

Published:22 December 2025

 

 

VCAN Is Essential for ERK5-Driven Tumorigenesis in Soft Tissue Sarcoma

Int J Biol Sci 2026; 22(5):2452-2468. doi:10.7150/ijbs.121402 This issueCite

Research Paper

Jaime Jiménez-Suárez1‡, Francisco J. Cimas1,2,3‡, José Joaquín Paricio1,4, Borja Belandia5, Yosra Berrouayel6, Elena Arconada-Luque1, Sofía Matilla-Almazán7, Cesare Soffientini8, Stefano Percio8, Silvia Redondo-García9#, Natalia García-Flores1, Cristina Garnés-García1, Pablo Fernández-Aroca1, Juan Jesús Martínez-Gómez1, Antonio Fernández-Aramburo1,10, Syong Hyun Nam-Cha1,3, Elisabetta Rovida11, Atanasio Pandiella7, Azucena Esparís-Ogando7, Sandro Pasquali8, Juan Carlos Rodríguez-Manzaneque9, Luis Del Peso6, María José Ruiz-Hidalgo1,2,3,12* Corresponding address, Ricardo Sánchez-Prieto1,3,5,12,13* Corresponding address

1. Universidad de Castilla-La Mancha, Laboratorio de Oncología Molecular, Unidad de Medicina Molecular, Instituto de Biomedicina, Unidad Asociada de Biomedicina UCLM, Unidad Asociada al CSIC, Albacete, Spain.
2. Universidad de Castilla-La Mancha, Departamento de Química Inorgánica, Orgánica y Bioquímica, Área de Bioquímica y Biología Molecular. Facultad de Medicina, Albacete, Spain.
3. Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM).
4. Servicio de Anatomía Patológica, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
5. Departamento de Biología del Cáncer, Instituto de Investigaciones Biomédicas “Sols-Morreale” (CSIC-UAM), Unidad Asociada de Biomedicina UCLM, Unidad Asociada al CSIC, Madrid, Spain.
6. Departamento de Bioquímica, Universidad Autónoma de Madrid (UAM) and Instituto de Investigaciones Biomédicas “Sols-Morreale” (CSIC-UAM), Madrid, Spain. Unidad Asociada de Biomedicina UCLM, Unidad Asociada al CSIC, Madrid, Spain. CIBERES, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Madrid, Spain.
7. Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain, Instituto de Biología Molecular y Celular del Cáncer (IBMCC)-CSIC, Salamanca, Spain, Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), CSIC-Universidad de Salamanca, Salamanca, Spain.
8. Molecular Pharmacology, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
9. GENYO. Centre for Genomics and Oncological Research: Pfizer/Universidad de Granada/Junta de Andalucía, Granada, Spain.
10. Sección de Oncología Médica, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
11. Department of Clinical and Experimental Biomedical Sciences, University of Florence, Viale G.B. Morgagni, 50, Florence, 50134, Italy.
12. Translational Cancer Research Group, Chronic Diseases and Cancer, Area 3, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain.
13. CSIC Conexión-Cáncer Hub, Madrid, Spain.
‡ These authors contributed equally to this work.
# Present address: Antibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.
* Both senior authors have contributed by equal to this work.

Corresponding authors: rsprieto@iib.uam.es.

Received 2025-7-10; Accepted 2026-1-19; Published 2026-2-4

 

Journal of Molecular Structure

Synthesis, photophysical properties, and two-photon absorption behavior of pyrimidinyl urea derivatives

Author links open overlay panelJulián Rodríguez-López a, Eleftherios Laleas b, Elio G. Soultse bMihalis Fakis bSylvain Achelle c

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https://doi.org/10.1016/j.molstruc.2026.145438Get rights and content

Under a Creative Commons license

 

Mitochondrial Dysfunction Contributes to Decompensation in a Zebrafish Model of Isoproterenol-Induced Heart Failure

Manuel VicenteAaron García-BlázquezAntonio Martínez-SielvaJussep Salgado-AlmarioJoaquín JordánBeatriz DomingoJuan Llopis

First published: 31 October 2025

 

https://doi.org/10.1111/apha.70128Digital Object Identifier (DOI)

 

Funding: This work was supported by the Ministry of Science, Innovation and Universities, Spain (PID2022-141928NB-I00 to J.L. and B.D.) and by EU FEDER-ERDF (PID2022-141928NB-I00 to J.L. and B.D.); and the University of Castilla-La Mancha, co-funded by EU FEDER-ERDF (2022-GRIN-34301 to J.L.).

 

 

 

 

Frontiers in Sports and Active Living

2025

Changes in cortical brain activity after active break in preschoolers: MOVI-HIIT study

Valdivieso González, María; Francisco Javier Sancho Bielsa; Beatriz García Martínez; Arturo Martínez Rodrigo; Óscar Navarro Martínez; Andrés Redondo Tébar; Mairena Sánchez López;

 

Improving Good Practices for Patient Safety in an Emergency Department Based on Multidisciplinary Training Using Simulation Techniques

by Francisco Javier Redondo Calvo 1,2,3,*ORCID,Victor Baladrón González 1,2,4ORCID,María Ángeles Tebar Betegón 5,6,Alejandro Martínez Arce 4,5,Gema Verdugo Moreno 3,7,Juan Fernando Padin 2ORCID,Laura Muñoz de Morales-Romero 5,8,Alberto Bermejo-Cantarero 5,8ORCID andNatalia Bejarano Ramírez 2,4,9ORCID

Nurs. Rep. 202515(10), 351; https://doi.org/10.3390/nursrep15100351

Submission received: 21 August 2025 / Revised: 21 September 2025 / Accepted: 25 September 2025 / Published: 26 September 2025

 

 

Combined administration of cocaine and alcohol alters the expression of brain peptide/protein profiles in rats: a MALDI imaging mass spectrometry approach

AlbertoMarcosa1PilarAlberdib1Carlos A.Castillo-SarmientocdEmilioAmbrosioa2InmaculadaBallesteros-Yáñezbd2

Received 7 October 2024, Revised 19 June 2025, Accepted 24 June 2025, Available online 10 July 2025, Version of Record 14 July 2025

 

Efficacy of respiratory physiotherapy preceding to heart surgery with extracorporeal circulationEficacia de la fisioterapia respiratoria previa a la cirugía cardiaca con circulación extracorpórea

Author links open overlay panelEloy Rueda-Gomariz a, Carlos A. Castillo-Sarmiento b, José Ramón Muñoz-Rodríguez c, Inmaculada Ballesteros-Yánez d

 

 

 

 

 

 

Ambient Levels of Carbonyl Compounds and Ozone in a Golf Course in Ciudad Real, Spain: A ProtoPRED QSAR (Eco) Toxicity Evaluation

by Alberto Moreno 1,2,*ORCID,Yoana Rabanal-Ruiz 2,3,4ORCID,Andrés Moreno-Cabañas 2,Carlos Sánchez Jiménez 1,2 andBeatriz Cabañas 1,2ORCID

Air 20253(1), 2; https://doi.org/10.3390/air3010002

Submission received: 31 October 2024 / Revised: 24 December 2024 / Accepted: 26 December 2024 / Published: 6 January 2025

 

 

Food Hydrocolloids

2025

Corn silk as an underutilized sustainable source of plant proteins: Extraction, fractionation, structure, and techno-functional properties

Orellana Palacios, Jose Carlos; Rodríguez García, Samuel; Yoana Rabanal Ruiz; Mcclements , David Julian; Andrés Moreno Moreno; Hadidi , Milad;

 

 

Spanish Journal of Psychiatry and Mental Health 2025

Oxytocin and rejection sensitivity: A comparative biomarker study in women with borderline personality and eating disorders

Francisco Ruiz-Guerreroa bAlejandrode la Torre-LuquecdKarinaMacDowellcghLuisBeato-FernándezfJuan C.LezacghMarinaDiaz-Marsacde

 

 

Histology and Histopathology 2025

G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels: Molecular, cellular, and subcellular diversity

Alejandro Martín Belmonte; Carolina Aguado Rubio; Rocío Alfaro Ruiz; Rafael Luján Miras;

 

 

 

 

 


Perspective

Amyloid-beta pathology–induced nanoscale synaptic disruption: the case of the GABAB–GIRK assembly

Luján, Rafael*; Martín-Belmonte, Alejandro; Ferré, Sergi; Ciruela, Francisco*

Author Information

Neural Regeneration Research 20(5):p 1409-1410, May 2025.DOI: 10.4103/NRR.NRR-D-24-00291

 

 

Amyloid-beta pathology–induced nanoscale synaptic disruption: the case of the GABAB–GIRK assembly

Luján, Rafael*; Martín-Belmonte, Alejandro; Ferré, Sergi; Ciruela, Francisco*

Author Information

Neural Regeneration Research 20(5):p 1409-1410, May 2025.DOI: 10.4103/NRR.NRR-D-24-00291

 

 

 

 

British Journal of Pharmacology

Chronic ethanol exposure in mice evokes pre- and postsynaptic deficits in GABAergic transmission in ventral tegmental area GABA neurons

Eric H. MittenAnna SoudersEzequiel Marron Fernandez de VelascoCarolina AguadoRafael LujánKevin Wickman

First published: 02 October 2024

 

https://doi.org/10.1111/bph.17335

 

neurology

Circulating miRNAs Associated With 3-Month Outcome in Patients With Acute Ischemic Stroke

Tomás Segura Martín

 

 

Trans-synaptic modulation of cholinergic circuits tunes opioid reinforcement

Stefano Zucca https://orcid.org/0000-0002-8781-3295Gloria BrunoriHenry A. Dunn, +7 , and Kirill A. Martemyanov https://orcid.org/0000-0002-9925-7599 kmartemyanov@ufl.eduAuthors Info & Affiliations

Edited by Thomas Südhof, Stanford University, Stanford, CA; received May 14, 2024; accepted February 16, 2025

March 20, 2025

122 (12) e2409325122

https://doi.org/10.1073/pnas.24093251

 

 

 

 

 

 

 

 

 

Role of Advanced Glycation End Products in Mediating Glycated Haemoglobin and Pulse Wave Velocity in Healthy Adults

by :Irene Martínez-GarcíaAlicia Saz, LaraCarlos Pascual-MorenaAna Díez-Fernández, Sara Valladolid-Ayllón, Bruno Bizzozero-Peroni, Óscar Martínez-Cifuentes, Eva Rodríguez-Gutiérrez and Iván Cavero-Redondo

CarVasCare Research Group, Facultad de Enfermería de Cuenca, Universidad de Castilla-La Mancha, 16071 Cuenca, Spain

Health and Social Research Center, Universidad de Castilla-La Mancha, 16071 Cuenca, Spain

Facultad de Enfermería de Albacete, Universidad de Castilla-La Mancha, 02006 Albacete, Spain

Hospital General Universitario de Elda, 03600 Elda, Spain

Higher Institute of Physical Education, Universidad de la República, Rivera 40000, Uruguay

Hospital Universitario Mutua Terrassa, 08221 Terrassa, Spain

Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS), 16071 Cuenca, Spain

Author to whom correspondence should be addressed.

Biomedicines 202513(1), 137; https://doi.org/10.3390/biomedicines13010137

Submission received: 13 December 2024 / Revised: 5 January 2025 / Accepted: 7 January 2025 / Published: 8 January 2025

 

Reference Values of Skin Autofluorescence by Age Groups in Healthy Spanish Adults: Results from the EVasCu Study, a Systematic Review, and a Meta-Analysis

by Irene Martínez-García, Iván Cavero-Redondo, Carlos Pascual-Morena, Iris Otero-Luis, Marta Fenoll-Morate, Carla Geovanna Lever-Megina, Eva Rodríguez-Gutiérrez and Alicia Saz-Lara

CarVasCare Research Group (2023-GRIN-34459), Faculty of Nursing, Universidad de Castilla-La Mancha, 16002 Cuenca, Spain

Health and Social Research Center, Universidad de Castilla-La Mancha, 16002 Cuenca, Spain

Facultad de Enfermería de Albacete, Universidad de Castilla-La Mancha, 02008 Albacete, Spain

Research Network on Chronicity, Primary Care and Health Promotion (RICAPPS), 16071 Cuenca, Spain

Author to whom correspondence should be addressed.

J. Clin. Med. 202514(2), 474; https://doi.org/10.3390/jcm14020474

Submission received: 10 December 2024 / Revised: 7 January 2025 / Accepted: 10 January 2025 / Published: 13 January 2025

(This article belongs to the Section Dermatology)

 

Donepezil Nanoemulsion Induces a Torpor-like State with Reduced Toxicity in Nonhibernating Xenopus laevis TadpolesClick to copy article link

Maria Plaza OliverErica GardnerTiffany LinKatherine SheehanMegan M. SperryShanda LightbownManuel Ramsés MartínezDaniela del CampoHaleh FotowatMichael LewandowskiTakako TakedaAlexander C. PauerShruti KaushalVaskar GnyawaliMaria V. LozanoManuel J. Santander OrtegaRichard NovakMichael SuperDonald E. Ingber*

 

Journal of General VirologyUbiquitin-like modifier-activating enzyme 1 interacts with Zika virus NS5 and promotes viral replication in the infected cellImanol Rodrigo Quintanar; Laura Albentosa González; María José Romero de Ávila García-Uceda; Rosaria Bassi, María; Navarro Sempere, Raquel; Pilar Clemente Casares; Armando Arias Esteban;

 

Verónica Astillero López; Sandra Villar Conde; Melania González Rodríguez; Alicia María Flores Cuadrado; Isabel María Úbeda Bañón; Daniel Saiz Sánchez; Alino José Martínez Marcos. “Proteomic analysis identifies HSP90AA1, PTK2B, and ANXA2 in the human entorhinal cortex in Alzheimer's disease: Potential role in synaptic homeostasis and Aß pathology through microglial and astroglial cells”. Brain Pathology 2024;e13235. https://doi.org/10.1111/bpa.13235

 

María López-Sepúlveda Ortega; José Carlos Orellana Palacios; Samuel Rodríguez García; Yoana Rabanal Ruiz; Andrés Moreno Moreno; Milad Hadidi. “Olive leaf protein: Extraction optimization, in vitro digestibility, structural and techno-functional properties”. International Journal of Biological MacromoleculesVolume 256, Part 1, January 2024, 128273.https://doi.org/10.1016/j.ijbiomac.2023.128273

 

Sergio Muñoz-VillaverdeMaría Martínez-GarcíaLeticia Serrano-OviedoFrancisco Javier Gómez-RomeroAna María Sobrado-SobradoMaría Ángeles Cidoncha-MorenoJuan Riesgo-MartínGuillermo Pedreira-Robles & Paloma Garcimartin“Impact of telenurse-led intervention in clinical trials on health literacy, empowerment, and health outcomes in patients with solid tumours: a pilot quasi-experimental study”. BMC Nursing volume 23: 86 (2024). DOI: 10.1186/s12912-023-01641-x

 

Beatriz Navarro Bravo,María Verónica Jimeno Jiménez, María de la Luz Fernández Aguilar, Marta Nieto López, Abel Toledano González, María José Cantero,  Laura Ros Segura,  José Miguel Latorre Postigo.” Effects of affectively-loaded childhood-related photos from the IAPS on the induction of involuntary autobiographical memories in young and older adults”. Front. Psychol., 11 January 2024. Sec. Psychology of Aging, Volume 14.https://doi.org/10.3389/fpsyg.2023.1266758

 

María José Romero de Ávila García-Uceda; Susana López López; Aarón García Blázquez; Almudena Ruiz García; María Julia González Gómez; María Luisa Nueda Sanz; Victoriano Baladrón García; Perez-Roger, Ignacio; Poch, Enric; Ballester-Lurbe, Begoña; José Javier García Ramírez; Eva María Monsalve Argandoña; María José Martínez Díaz-Guerra. “RND3 Potentiates Proinflammatory Activation through NOTCH Signaling in Activated Macrophages”. Journal of Immunology Research, Volume 2024. Article ID 2264799. DOI: 10.1155/2024/2264799