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Publicaciones

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ojas K, Baliu-Piqué M, Manzano A, Saiz-Ladera C, García-Barberán V, Cimas FJ, Pérez-Segura P, Pandiella A, Győrffy B, Ocana A. In silico transcriptomic mapping of integrins and immune activation in Basal-like and HER2+ breast cancer.Cell Oncol (Dordr). 2021 Jan 19. doi: 10.1007/s13402-020-00583-9. PMID: 33469836

 

Nieto-Jimenez C, Alcaraz-Sanabria A, Martinez-Canales S, Corrales-Sanchez V, Montero JC, Burgos M, Nuncia-Cantarero M, Pandiella A, Galan-Moya EM*, Ocaña A*.Checkpoint Kinase 1 Pharmacological Inhibition Synergizes with DNA-Damaging Agents and Overcomes Platinum Resistance in Basal-Like Breast Cancer.Int J Mol Sci. 2020 Nov 27;21(23):9034. doi:10.3390/ijms21239034.PMID: 33261142


Cimas FJ, Niza E, Juan A, Noblejas-López MDM, Bravo I, Lara-Sanchez A, Alonso-Moreno C, Ocaña A. Controlled Delivery of BET-PROTACs: In Vitro Evaluation of MZ1-Loaded Polymeric Antibody Conjugated Nanoparticles in Breast Cancer. Pharmaceutics. 2020 Oct 19;12(10):986. doi: 10.3390/pharmaceutics12100986. PMID: 33086530

Cimas FJ, Manzano A, Baliu-Piqué M, García-Gil E, Pérez-Segura P, Nagy Á, Pandiella A, Győrffy B, Ocana A. Genomic Mapping Identifies Mutations in RYR2 and AHNAK as Associated with Favorable Outcome in Basal-Like Breast Tumors Expressing PD1/PD-L1.Cancers (Basel). 2020 Aug 11;12(8):2243. doi: 10.3390/cancers12082243. PMID: 32796628

 

Nieto-Jimenez C, Galan-Moya EM*, Corrales-Sanchez V, Noblejas-Lopez MDM, Burgos M, Domingo B, Montero JC, Gomez-Juarez M, Picazo-Martinez MG, Esparis-Ogando A, Pandiella A, Ocaña A*.Inhibition of the mitotic kinase PLK1 overcomes therapeutic resistance to BET inhibitors in triple negative breast cancer.Cancer Lett. 2020 Oct 28;491:50-59. doi: 10.1016/j.canlet.2020.06.020. PMID: 32735909

 

ÇSantiago JL, Galan-Moya EM, Muñoz-Rodriguez JR, de la Cruz-Morcillo MA, Redondo-Calvo FJ, Gracia-Fernandez I, Elias PM, Perez-Ortiz JM, Man MQ. Topical Applications of Thiosulfinate-Enriched Allium sativum Extract Accelerates Acute Cutaneous Wound Healing in Murine Model.Chin J Integr Med. 2020 Nov;26(11):812-818. doi: 10.1007/s11655-020-3086-7. PMID: 32418180

 

Perez-Ortiz JM, Galan-Moya EM, de la Cruz-Morcillo MA, Rodriguez JF, Gracia I, Garcia MT, Redondo-Calvo FJ. Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer.Int J Mol Sci. 2020 Apr 16;21(8):2766. doi: 10.3390/ijms21082766.

PMID: 32316312

Serrano-Oviedo L, Nuncia-Cantarero M, Morcillo-Garcia S, Nieto-Jimenez C, Burgos M, Corrales-Sanchez V, Perez-Peña J, Győrffy B, Ocaña A, Galán-Moya EM. Identification of a stemness-related gene panel associated with BET inhibition in triple negative breast cancer.Cell Oncol (Dordr). 2020 Jun;43(3):431-444. doi: 10.1007/s13402-020-00497-6. PMID: 32166583

 

Corrales-Sánchez V, Noblejas-López MDM, Nieto-Jiménez C, Pérez-Peña J, Montero JC, Burgos M, Galán-Moya EM, Pandiella A, Ocaña A. Pharmacological screening and transcriptomic functional analyses identify asynergistic interaction between dasatinib and olaparib in triple-negative breast cancer.J Cell Mol Med. 2020 Mar;24(5):3117-3127. doi: 10.1111/jcmm.14980.PMID: 32032474

 

Alcaraz-Sanabria A, Baliu-Piqué M, Saiz-Ladera C, Rojas K, Manzano A, Marquina G, Casado A, Cimas FJ, Pérez-Segura P, Pandiella A, Gyorffy B, Ocana A. Genomic Signatures of Immune Activation Predict Outcome in Advanced Stages of Ovarian Cancer and Basal-Like Breast Tumors.Front Oncol. 2020 Jan 10;9:1486. doi: 10.3389/fonc.2019.01486. eCollection 2019.PMID: 31998644

Noblejas-López MDM, Nieto-Jiménez C, Morcillo García S, Pérez-Peña J, Nuncia-Cantarero M, Andrés-Pretel F, Galán-Moya EM, Amir E, Pandiella A, Győrffy B, Ocana A.Expression of MHC class I, HLA-A and HLA-B identifies immune-activated breast tumors with favorable outcome.Oncoimmunology. 2019 Jul 3;8(10):e1629780. doi: 10.1080/2162402X.2019.1629780. PMID: 31646075 

 

Noblejas-López MDM, Nieto-Jimenez C, Burgos M, Gómez-Juárez M, Montero JC, Esparís-Ogando A, Pandiella A, Galán-Moya EM*, Ocaña A*.Activity of BET-proteolysis targeting chimeric (PROTAC) compounds in triple negative breast cancer.J Exp Clin Cancer Res. 2019 Aug 30;38(1):383. doi: 10.1186/s13046-019-1387-5. PMID: 31470872 

 

Morcillo-Garcia S, Noblejas-Lopez MDM, Nieto-Jimenez C, Perez-Peña J, Nuncia-Cantarero M, Győrffy B, Amir E, Pandiella A, Galan-Moya EM, Ocana A. Genetic mutational status of genes regulating epigenetics: Role of the histone methyltransferase KMT2D in triple negative breast tumors. PLoS One. 2019 Apr 16;14(4):e0209134. doi: 10.1371/journal.pone.0209134. PMID: 30990809

 

Pérez-Pena J, Páez R, Nieto-Jiménez C, Sánchez VC, Galan-Moya EM, Pandiella A, Győrffy B, Ocana A. Mapping Bromodomains in breast cancer and association with clinical outcome. Sci Rep. 2019 Apr 5;9(1):5734. doi: 10.1038/s41598-019-41934-3.PMID: 30952871

 

Garaud S, Taher TE, Debant M, Burgos M, Melayah S, Berthou C, Parikh K, Pers JO, Luque-Paz D, Chiocchia G, Peppelenbosch M, Isenberg DA, Youinou P, Mignen O, Renaudineau Y, Mageed RA.  CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes. Cell Mol Immunol. 2018 Feb;15(2):158-170. doi: 10.1038/cmi.2016.42

 

Noblejas-López MDM, Morcillo-García S, Nieto-Jiménez C, Nuncia-Cantarero M, Győrffy B, Galan-Moya EM*, Pandiella A, Ocaña A*.Evaluation of transcriptionally regulated genes identifies NCOR1 in hormone receptor negative breast tumors and lung adenocarcinomas as a potential tumor suppressor gene.PLoS One. 2018 Nov 28;13(11):e0207776. doi: 10.1371/journal.pone.0207776. PMID: 30485330

 

Martínez-Canales S, López de Rodas M, Nuncia-Cantarero M, Páez R, Amir E, Győrffy B, Pandiella A, Galán-Moya EM*, Ocaña A*. Functional transcriptomic annotation and protein-protein interaction analysis identify EZH2 and UBE2C as key upregulated proteins in ovarian cancer.Cancer Med. 2018 May;7(5):1896-1907. doi: 10.1002/cam4.1406. PMID: 29575713

 

Nuncia-Cantarero M, Martinez-Canales S, Andrés-Pretel F, Santpere G, Ocaña A, Galan-Moya EM. Functional transcriptomic annotation and protein-protein interaction network analysis identify NEK2, BIRC5, and TOP2A as potential targets in obese patients with luminal A breast cancer. Breast Cancer Res Treat. 2018 Apr;168(3):613-623. doi: 10.1007/s10549-017-4652-3. PMID: 29330624

 

Alcaraz-Sanabria A, Nieto-Jiménez C, Corrales-Sánchez V, Serrano-Oviedo L, Andrés-Pretel F, Montero JC, Burgos M, Llopis J, Galán-Moya EM, Pandiella A, Ocaña A. Synthetic Lethality Interaction Between Aurora Kinases and CHEK1 Inhibitors in Ovarian Cancer.Mol Cancer Ther. 2017 Nov;16(11):2552-2562. doi: 10.1158/1535-7163.MCT-17-0223. PMID: 28847989

Martínez-Canales S, Cifuentes F, López De Rodas Gregorio M, Serrano-Oviedo L, Galán-Moya EM, Amir E, Pandiella A, Győrffy B, Ocaña A. Transcriptomic immunologic signature associated with favorable clinical outcome in basal-like breast tumors.PLoS One. 2017 May 4;12(5):e0175128. doi: 10.1371/journal.pone.0175128. PMID: 28472085

 

Nieto-Jiménez C, Alcaraz-Sanabria A, Pérez-Peña J, Corrales-Sánchez V, Serrano-Heras G, Galán-Moya EM, Serrano-Oviedo L, Montero JC, Burgos M, Llopis J, Pandiella A, Ocaña A. Targeting basal-like breast tumors with bromodomain and extraterminal domain (BET) and polo-like kinase inhibitors. Oncotarget. 2017 Mar 21;8(12):19478-19490. doi: 10.18632/oncotarget.14465. PMID: 28061448

 

9Bakayan A1, Domingo B, Miyawaki A, Llopis J. Imaging Ca2+ activity in mammalian cells and zebrafish with a novel red-emitting aequorin variant. Pflugers Arch. 2015;467(9):2031-42. doi: 10.1007/s00424-014-1639-3. [Epub 2014].

 

Caminos E, Vaquero CF, Martínez-Galan JR. Relationship between rat retinal degeneration and potassium channel KCNQ5 expression. Exp Eye Res. 2015; 131:1-11. doi: 10.1016/j.exer.2014.12.009. [Epub 2014]. (A). 

 

Llorens S, Arribas E, Arroyo MM, Artacho E, Carmona M, Domingo B, Fernández M, Insausti R, Jordán J, Legidos ME, Marcos P, Mohedano A, Muñoz M, Vaquero CF, Nájera A. Evaluation of the possible impact of clickers on the grade obtained by studens in the radiology subject, at the Faculty of Medicine in Albacete. En: INTED2014 Proceedings. 2014; 2707-2714. Ed. INTED. ISBN: 978-84-616-8412-0.. (CL). 

 

Domingo B, Arribas E, Arroyo MM, Artacho E, Carmona M, Fernández M, Insausti R, Jordán J, Lejidos ME, Marcos P, Mohedano A, Muñoz M, Nájera A, Vaquero CF, Llorens S. The impact of concept-test activities with classroom response systems (clickers) in physiology in Medicine School of Albacete. En: INTED2014 Proceedings. 2014; 2761 2767. Ed. INTED. ISBN: 978-84-616-8412-0.. (CL). 

 

Festuccia C, Mancini A, Gravina GL, Scarsella L, Llorens S, Alonso GL, Tatone C, Di Cesare E, Jannini EA, Lenzi A, D’Alessandro AM, Carmona M. Antitumor effects of saffron-derived carotenoids in prostate cancer cell models.Biomed Res Int. 2014;2014:135048. doi: 10.1155/2014/135048. (A). 

 

Mancini A, Serrano-Díaz J, Nava E, D’Alessandro AM, Alonso GL, Carmona M, Llorens S. Crocetin, a Carotenoid Derived from Saffron ( Crocus sativus L.), Improves Acetylcholine-Induced Vascular Relaxation in Hypertension.J Vasc Res. 2014;51(5):393-404. doi: 10.1159/000368930. (A). 

 

Caminos E, Vaquero CF, García-Olmo DC. ‘Green Mice’ display limitations in enhanced green fluorescent protein expression in retina and optic nerve cells. Histol Histopathol. 2014; 29(12):1601-12. (A).

Ferraz-Nogueira JP, Díez-Guerra FJ, Llopis J. Visualization of phosphatidic Acid fluctuations in the plasma membrane of living cells. PLoS One. 2014; 9[7]:e102526. (A). 

 

Mendizábal Y, Llorens S, Nava E. Vasoactive effects of prostaglandins from the perivascular fat of mesenteric resistance arteries in WKY and SHROB rats. Life Sci. 2013;93(25-26):1023-32. doi: 10.1016/j.lfs.2013.10.021. (A). 

 

Mendizábal Y, Llorens S, Nava E. Hypertension in metabolic syndrome: vascular pathophysiology. Int J Hypertens. 2013; 2013:230868. [doi: 10.1155/2013/230868].  

 

Lisa S, Domingo B, Martinez J, Gilch S, Llopis JF, Schatzl HM, Gasset M. Failure of prion protein oxidative folding guides the formation of toxic transmembrane forms. J Biol Chem. 2012; 287(44):36693-36701. (A). 

 

Prieto-Martín AI, Llorens S, Pardal-Fernández JM, Muñoz LJ, López DE, Escribano J, Nava E, de Cabo C. Opposite caudal versus rostral brain nitric oxide synthase response to generalized seizures in a novel rodent model of reflex epilepsy. Life Sci. 2012. 90[13-14]]: 531-537. (A)