Los investigadores integrantes del grupo de investigación acumulan décadas de experiencia en el estudio de la estructura y función del sistema nervioso auditivo. Han realizado contribuciones relevantes para comprender la organización funcional de las conexiones sinápticas de los núcleos auditivos centrales y de los cambios plásticos moleculares y celulares en núcleos auditivos tras sordera experimental. Los logros recientes más destacables incluyen:

-Ofrecer evidencias experimentales de que las sorderas producidas por ruido pueden revertir al menos parcialmente con la administración oral de vitaminas antioxidantes y Mg++ y posibles mecanismos de este efecto

-Ofrecer evidencias experimentales de que las sorderas producidas por antibióticos ototóxicos y cisplatino pueden revertir al menos parcialmente con la administración oral de vitaminas antioxidantes y Mg++ y posibles mecanismos de este efecto.

-Ofrecer evidencias experimentales de que las sorderas relacionadas con el envejecimiento pueden revertir al menos parcialmente con la administración oral de vitaminas antioxidantes y Mg++ y posibles mecanismos de este efecto.

-Ofrecer evidencias experimentales del papel de las células de glía en mecanismos plásticos de adaptación a sorderas.

 

Researchers in the lab accumulate decades of experience in the study of the structure and function of the auditory nervous system. They have made relevant contributions to understand the functional organization of the synaptic connections of the central auditory nuclei and of the molecular and cellular plastic changes in auditory nuclei after experimental deafness. The most notable recent achievements include:

-Offer experimental evidence that deafness produced by noise can revert at least partially with the oral administration of antioxidant vitamins and Mg ++ and possible mechanisms of this effect

-Offer experimental evidence that deafness produced by ototoxic antibiotics and cisplatinum can reverse at least partially with the oral administration of antioxidant vitamins and Mg ++ and possible mechanisms of this effect.

-Offer experimental evidence that deafness related to aging can revert at least partially with the oral administration of antioxidant vitamins and Mg ++ and possible mechanisms of this effect.

-Offer experimental evidences of the role of glia cells in plastic mechanisms of adaptation to deafness.

Publicaciones más relevantes

Fuentes-Santamaría V, Alvarado JC, Melgar-Rojas P, Gabaldón-Ull MC, Miller JM, Juiz JM. The Role of Glia in the Peripheral and Central Auditory System Following Noise Overexposure: Contribution of TNF-α and IL-1β to the Pathogenesis of Hearing Loss. Front Neuroanat. 2017 Feb 23;11:9. doi: 10.3389/fnana.2017.00009. eCollection 2017.

Alvarado JC, Fuentes-Santamaría V, Melgar-Rojas P, Valero ML, Gabaldón-Ull MC, Miller JM and Juiz JM (2015) Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing loss. Front. Aging Neurosci. 7:86. doi: 10.3389/fnagi.2015.00086

Alvarado JC, Fuentes-Santamaría V, Gabaldón-Ull MC, Blanco JL and Juíz JM (2014) Wistar rats: a forgotten model of age-related hearing loss. Front. Aging Neurosci. 6:29. doi: 10.3389/fnagi.2014.00029

Fuentes-Santamaría V, Alvarado JC, Gabaldón-Ull MC, Manuel Juiz J. Upregulation of insulin-like growth factor and interleukin 1β occurs in neurons but not in glial cells in the cochlear nucleus following cochlear ablation. J Comp Neurol. 2013 Oct 15;521(15):3478-99. doi: 10.1002/cne.23362.

Lamas V, Alvarado JC, Carro J, Merchán MA. Long-term evolution of brainstem electrical evoked responses to sound after restricted ablation of the auditory cortex. PLoS One. 2013 Sep 16;8(9):e73585. doi: 10.1371/journal.pone.0073585. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/07ec3908-23dd-4c31-926d-9d73a2815032.

Alvarado JC, Fuentes-Santamaría V, Jareño-Flores T, Blanco JL, Juiz JM. Normal variations in the morphology of auditory brainstem response (ABR) waveforms: a study in Wistar rats. Neurosci Res. 2012 Aug;73(4):302-11. doi:10.1016/j.neures.2012.05.001.

Publicaciones más recientes

Poveda CM, Valero ML, Pernia M, Alvarado JC, Ryugo DK, Merchan MA, Juiz JM (2020) Expression and Localization of Kv1.1 and Kv3.1b Potassium Channels in the Cochlear Nucleus and Inferior Colliculus After Long-Term Auditory Deafferentation. Brain Sci
. 2020 Jan 8;10(1):35. doi: 10.3390/brainsci10010035

Fuentes-Santamaría V, Alvarado JC, Rodríguez-de La Rosa L, Juiz JM and Varela-Nieto I (2019) Neuroglial Involvement in Abnormal Glutamate Transport in the Cochlear Nuclei of the Igf1 −/− Mouse. Front. Cell. Neurosci. 13:67. doi: 10.3389/fncel.2019.00067. eCollection 2019.

Alvarado JC, Fuentes-Santamaría V, Gabaldón-Ull MC and Juiz JM (2019) Age-Related Hearing Loss Is Accelerated By Repeated

Short-Duration Loud Sound Stimulation. Front. Neurosci. 13:77. doi: 10.3389/fnins.2019.00077. eCollection 2019.

Alvarado JC, Fuentes-Santamaría V, Gabaldón-Ull MC, Juiz JM. An Oral Combination of Vitamins A, C, E, and Mg ⁺⁺ Improves Auditory Thresholds in Age-Related Hearing Loss. Front Neurosci. 2018 Jul 31;12:527. doi: 10.3389/fnins.2018.00527. eCollection 2018.

Pernia M, Estevez S, Poveda C, Plaza I, Carro J, Juiz JM, Merchan MA. c-Fos and Arc/Arg3.1 expression in auditory and visual cortices after hearing loss: Evidence of sensory crossmodal reorganization in adult rats. J Comp Neurol. 2017 Aug 15;525(12):2677-2689. doi: 10.1002/cne.24233. Epub 2017.

Fuentes-Santamaría V, Alvarado JC, Melgar-Rojas P, Gabaldón-Ull MC, Miller JM, Juiz JM. The Role of Glia in the Peripheral and Central Auditory System Following Noise Overexposure: Contribution of TNF-α and IL-1β to the Pathogenesis of Hearing Loss. Front Neuroanat. 2017 Feb 23;11:9. doi: 10.3389/fnana.2017.00009. eCollection 2017.

Actualmente el grupo cuenta con los siguientes proyectos vivos, financiados de manera competitiva.

-Una combinación de estimulación transcraneal y otoprotección como nueva perspectiva para el tratamiento de sorderas neurosensoriales (SAF 2016 78898 C2-1-R). Ministerio de Ciencia, Innovación y Universidades, Gobierno de España (IPs: José M. Juiz/Verónica Fuentes)

-Sorderas neurosensoriales y fármacos ototóxicos: nuevas estrategias traslacionales para el tratamiento de un problema de salud y calidad de vida en Castilla-La Mancha (SBPLY/17/180501/000544).  Consejería de Educación y Cultura, Gobierno de Castilla-La Mancha (IPs: José M. Juiz/Juan C. Alvarado).

 

  

Currently the group has the following funded projects, financed in a competitive manner.

-A combination of transcranial stimulation and otoprotection as a new perspective for the treatment of sensorineural deafness (SAF 2016 78898 C2-1-R). Ministry of Science, Innovation and Universities, Government of Spain (IPs: José M. Juiz / Verónica Fuentes)

-Sensorineural hearing loss and ototoxic drugs: new translational strategies for the treatment of a health and quality of life issue in Castilla-La Mancha (SBPLY / 17/180501/000544). Regional Ministry of Education and Culture, Government of Castilla-La Mancha (IPs: José M. Juiz / Juan C. Alvarado).